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The phrase "play a difference" is correct and can be used in written English
It is typically used to refer to the impact someone or something has, such as with making a difference in the world. For example, "The nonprofit organization is working to play a difference in the lives of its community members."
Exact(2)
b In the cases of devices able to perform fast frequency hopping, and whose spectrum sensing and processing time is comparable to the frequency settling time, or in the games with smaller step sizes, this parameter would play a difference and should not be disregarded.
Doctors are beginning to understand, after decades of inconclusive evidence, that diet does play a difference in whether you get acne and how severe it is.
Similar(58)
Different methods of patient referral to nephrologists can play a role in difference in outcome.
Instead, other factors including genetic adaptation and acclimatisation could play a role in differences between cultural groups (23).
The school system may also play a role in differences in levels of depressive symptoms by gender.
Before heading to the airport, Watson took to the front steps of the Gleneagles hotel in an attempt to play down a "difference of opinion" with Mickelson.
These could, together, play a role in the difference seen in bacterial growth.
Venous mixing of the superior vena cava could play a role in this difference.
Also, turnover rates for mature mRNAs and miRNAs could play a role in the difference.
Thus it is unclear whether changes in peripheral inflammation might play a role in the difference between the genotypes.
It is found that temperature differences play a key role in the performances of energy storage when temperature differences are less than 20 °C.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com