Some of the putative mammary inductive signals expressed by cells in the mammary mesenchyme are found in the core interconnected network module and plausible signalling partners or signalling components have been identified in the mammary bud epithelium.
RSK is one of the many kinases that can phosphorylate rpS6 and since RSK is downstream of ERK, a plausible signaling pathway that is operating in the absence of SHB is ERK/RSK/rpS6.
This study shows a biologically plausible signal of intracellular acidosis associated with final tissue outcome.
The predicted network represents a biologically plausible signaling pathway specific to HepG2 cells, partially due to the novel graph search algorithm based on the Ontology Fingerprints.
After the base VEGFR network model was constructed, we sought a parameter set kinetic constants and protein abundances that provided biologically plausible signaling behavior.
Thus, one of several plausible signaling pathways to unlock orsellinic acid production by bacterial contact could also involve an oxidative stress-related pathway that co-activates Saga/Ada.
Combining prior knowledge with experimental data, we adopted a Bayesian network approach to infer the most plausible signaling network from a web of complex networks.
The delineated pathways were then combined into plausible signalling cascades and initial sub-models were manually assembled using the PathVisio software.
To evaluate whether this set of parameters provided biologically plausible signaling behavior, we simulated ligand-induced pERK and pAkt signaling dynamics in response to "strong" ligand stimulation (0.5 nmol/l VEGF).
For SMWD, three variants remained significant after conditioning: while two of them are most probably imputation artefacts, the third signal, rs112942398, looks like a much more plausible signal based on its regional plot.
