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Plausible resistance-related functions readily can be proposed for these and other expanded families of deinococci.
A similar approach is plausible for resistance alleles on chromosomal genes, such as streptomycin-resistance mutations on rpsL or rifampicin-resistance mutations on rpoB.
Therefore, it seems plausible that resistance development of PC3 cells may be accompanied by two different processes: (A) quantitative alterations of the integrin-expression level and (B) structural changes of the integrin molecules, leading to a switch of the intracellular pathway direction following short-term RAD001 treatment.
It is biologically plausible that insulin resistance is associated with endometrial cancer risk.
It is plausible that further resistance variants may confer protection against further virulence variants.
Therefore, it is plausible that insulin resistance might be reduced via appropriate anti-infective/anti-inflammatory periodontal therapy.
The relationship between type 2 diabetes and various forms of cancer is biologically plausible, with insulin resistance, hyperinsulinemia, and elevated levels of IGF-1 in patients with type 2 diabetes involved in promotion of tumor cell growth.
Therefore, it is plausible that the resistance to fluconazole that we observed with fet3Δ/fet3Δ and ftr1Δ/ftr1Δ mutants might be an influence on the drug's target, rather than its import.
3 Mutations in signaling components downstream of the initiating Erbb dimer and several interconnections between the two main signaling pathways MAPK and PI3 K-Akt of Erbb may bypass therapy suppression and are plausible explanations for resistance to trastuzumab in HER2-positve breast cancer and possibly also gastric cancer.
We understand that this proposed mechanism could be just one of the many plausible scenarios explaining resistance to EGFR-targeted therapies since alternative escape routes such as TGF- β and IL-6 axis have been implicated in other tumour types (Yao et al, 2010).
From our data we present a novel picture of competing signaling networks that collectively provide a plausible explanation of chemotherapeutic resistance, cancer stem cell survival, as well as invasiveness and metastases.
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