A burgeoning literature is devoted to discussing plausible requirements on BAFs.
The importance of high PRESS PRESSURE is entirely plausible, but the requirement for low AUGER SPEED is not so intuitive, and could not at first be explained by operators.
It is plausible given the requirement for both T4 structural genes and this peptidoglycan-degrading accessory factor, that the T4S apparatus facilitates the transfer of this protein to recipient cells, where it induces lysis.
The most plausible hypothesis is a requirement for a cofactor for Stbm:Pk binding, but other possibilities include saturation of the machinery for a posttranslational modification or a conformational change in Fmi.
This suggestion would provide a plausible explanation of the requirement for an expanded set of urochordate hemocyte integrins although more generic explanations, such as the preparation for a sessile life-style under attack by pathogens, are also possible.
This is important because even if PPARα agonism were to present a plausible MOA, an overriding requirement for reliance on that MOA as a sole indicator of human risk would be that other MOAs have been excluded.
There is a plausible way to weaken the requirement for genuine doubt by adding a fourth condition to conditions (1) – (3) (above), namely, that d must have some evidential support; for example, it must have sufficient support to make it plausible enough so as to require that it be shown to be false or at least neutralized.
A crucial requirement for any plausible mechanistic model of this system is that it reproduces the robustness of the bistable response observed in vivo against inter-individual parametric variability and fluctuating environmental conditions.
The molecular mechanisms supporting a hypersensitivity to exogenous DA are yet to be determined, though in the case of the dat-1 mutants, a plausible basis is a reduced requirement for exogenous DA to achieve DOP-3 activation in animals that cannot capitalize on the DA clearance activity provided by DAT-1.
In many cases, untrained and often inexperienced officers arrive at an incident and come up with a plausible story which then defines the response of everybody else down the line: to attack that plausible story may be an essential requirement for the discovery of the truth, but it flies in the face of the new values of criminal justice.
