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One of Irv and Jerry's major contributions was to propose a plausible mode of inheritance for schizophrenia.
Thiol-dependent oxidative damage to guanine in DNA is a plausible mode of action for bromate-induced cancer.
Through a pharmacophore approach, complementarities between the ligand and the binding site are explored and a plausible mode of binding with the protein is suggested for albidoside.
The plausible mode of action of these compounds was through sulfhydryl binding, confirmed via reduction in available free thiols on human sperm.
The plausible mode of inclusion and structure of the β-CD-FLN inclusion complex cannot be achieved only from 2D 1H-1H ROESY spectral data and therefore, another approach was required.
Modulation of hepatic sterol and steroid metabolism is a plausible mode of action for changes in serum testosterone and adverse reproductive outcomes observed in rat studies, and may be relevant to human risk assessment.
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Based on the structural data and docking analysis, a plausible mode-of-action for this novel class of FtsZ inhibitors is proposed.
Finally, the highly significant associations between basal gene expression variability and chemical-induced toxicity suggest plausible mode-of-action hypotheses for follow-up analyses.
Summarising, the responses discussed here all represent plausible modes of cellular disruption, and all of them have been demonstrated previously to be induced by copper exposure.
Recently, Dietz et al. (2006) took this approach to explore the effects of vaccination by altering several different model parameters corresponding to different (plausible) modes of vaccine action.
The analysis was limited to pesticides with potential developmental, antiandrogenic, estrogenic, or reproductive effects since they have biologically plausible modes of action to affect male urogenital development.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com