Models for the spread of infectious diseases are useful tools - can project plausible scenarios, guide control strategies, suggests roles of antiviral drugs and vaccines and so on.
Additional theoretical studies are required to delimit the range of parameter values that are plausible, and further guide the hypotheses to be tested.
The guide-tree topology was taken from the *BEAST analysis, all nodes of which were supported by a posterior probability of 1.0 and hence we did not need to test the effect on the species delimitation of any alternative plausible topology as guide-tree (compare with 56).
While the exclusion based on the lack of plausible results is guided by the analysis of the literature, the exclusion based on the importance of the outcomes implies a value judgement expressed by the panel at the outset of the process.
We might put the general point as follows: in object-rich domains, systematicity ceases even to be a reliable guide to plausible analogical inference.
This condition is plausible because no universal guide to behavior that applies to all rational persons can be based on beliefs that some of these rational persons do not share.
This model has suggested a novel, filopodia-mediated tip-cell selection mechanism, the molecular level of the model is experimentally plausible, and it has guided experimental studies (Jakobsson et al. 2010; Guarani et al. 2011).
The point, of course, is that our intuition has a hard time dealing both with the idea of selection and the sheer length of time evolution has to do its work, so your personal feeling that something isn't plausible is a very bad guide.
In either case, both formal principles give content to the intuitively plausible idea that chances should guide reasonable credence.[1] But one needn't accept precisely this version of the BCP to endorse the general thesis that chance and possibility must be linked for other versions of this kind of claim, see Mellor (2000); Eagle (2011) and the 'realization principle' of Schaffer (2007: 124).
It is certainly fine to speculate, but while it is formally plausible that the RRE may guide Rev into an array of dimers with multiple crossing angles upon protein-RNA contact, there is as yet no experimental basis for this and the hexamers modeled here are entirely speculative.
