The result was a more biologically plausible dose-response curve that captures better the physiological response to toxic insults at low doses and long-term (chronic) exposure.
Future work to understand infection processes in more detail for these microbes is necessary, not only for the sake of general knowledge, but also because the diversity of plausible dose-response functions for each microbe may yield different estimates of infection risk, and different risk management conclusions.
In the context of the dose-response characteristics for the adverse outcome, it is necessary to consider the plausible dose-response characteristics for each of the key events for a particular adverse outcome and further to establish if one or more of these is a determinant of the dose-response for the adverse outcome, either quantitatively or qualitatively.
Critical factors to consider in order to ensure relevance to public health decision making include: (1) the limitations and specific features of the animal model; (2) targeting the human population in the design of animal studies, specifically the appropriate developmental stage; and (3) the use of plausible environmental doses and Pb speciation.
Seeing the quick and almost full switch of bisphosphonates with daily to weekly dosing regimen [ 7], it is plausible that monthly dosing regimen would become one day the standard of oral bisphosphonates dosing frequency.
For the time being, because sunitinib plasma levels cannot be determined routinely, it seems plausible to consider dose re-escalation in fit patients upon signs of disease progression.
The biologically plausible, specific and dose- and time-dependant inverse association that we have found suggests that tricyclics may have potential for prevention of both colorectal cancer and glioma.
As proposed in that report, it is plausible that the dose of CDC and administration procedure used in our study might have limited the impact of increased GLP-2 secretion on intestinal adaptation to EW.
Target antigen expression in these tissues is a plausible explanation for dose-dependent uptake, as protein expression of CD44 has been reported for normal bone marrow, spleen, lung, kidney and liver (bile ducts) [16, 17].
It is plausible that with doses comparable to those used in this study a similar plateau effect may be detectable in adults.
Three further criteria are proposed that have the potential to increase this confidence: a large magnitude of effect with no plausible confounders, a dose-response gradient, and a conclusion that all plausible residual confounding would further support inferences regarding treatment effect.
