Therefore, it is plausible that ciliary trafficking defects, and/or defects in cilia formation, contribute to the pathogenesis of these diseases in both the OE and in the kidney.
As for PD, it is plausible that a defect in axonal guidance or maintenance or repair could predispose to ALS [2].
It is plausible that some defect or delay in the polarization might account for migration failure.
A plausible explanation for the defects in cerebellar foliation of the PEX13 brain mutants is the impaired migration of granule cells and abnormal Purkinje cell development.
Grocery store lane selection, it seems, is only the beginning of their issues, and perhaps ought not be viewed as the primary concern, as a more insidious ailment might be at work (a learning disability, brain wound or mental defect seems plausible).
It seems plausible that this trafficking defect might be critically dependent on the intracellular concentration of HbS, providing a mechanistic link between intracellular HbS concentration and cell surface PfEMP1 expression levels that can be tested in future work.
That life with a disability or chronic illness is predictably worse than non-existence is not plausible for most of the defects for which we test notably including Down syndrome, which is the most common target for testing and abortion, and for which a happy disposition is actually a characteristic trait.
The association between SSRIs and heart defects is biologically plausible; Sadler 27 has suggested that the association may be a result of the key role that the neurotransmitter serotonin (5-hydroxytryptamine) plays in embryonic development of the heart.
In contrast CD-high-CU children showed relative competency in cognitive, but deficits in affective-perspective taking, a finding that suggests an affective-specific defect and a plausible dissociation of affective and cognitive perspective-taking in CD-high-CU children.
It was therefore plausible to hypothesize that the defect of NK cells in aged mice could arise from defective IL-15 production in the bone marrow and that their numbers and maturation could be increased by IL-15/IL-15Rα IL-15/IL-15Rα IL-15/IL-15Rα
