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Although the analysis of the number of floating episodes (Fig. 2A) or the cumulative floating time (Fig. 2B) did not reveal a significant effect of genotype on floating behavior for the acquisition, visible, probe and reverse platform tasks (t = 0.130, P = 0.898, Student's t test), a clear difference in the floating pattern along sessions was observed between Dyrk1A+/− and wild type mice.
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Both groups of lesioned rats presented a deficit in the non-visible platform task but not in the visible platform one.
There were 1575 rows (679 neurons, 2 platforms from the 2 platform task and 217 neurons from the one platform task) and 2 columns (texture and reward location).
Despite a trend for CR group, only RSV supplementation increased spatial memory performances in the circular platform task.
RSV supplementation also significantly lowered the number of errors in the circular platform task compared to CTL whereas CR did not significantly change the performances to this test.
We tested the first prediction by identifying the texture that evoked the peak firing rate for all 147 neurons that discriminated between a single texture pair in the two platform task.
First, the Mbnl1−/− mice perform normally in the visible watermaze (Figure 4E) which involved three sequential trials compared to two sequential trials in the hidden platform task, and was performed after the hidden watermaze.
Indeed, CR animals did not make more errors to find the exit compared to CTL animals and both groups performed the same time to reach the exit in the circular platform task.
A second group was given the platform task first, followed by the water-tube task, with the same result.
Five subjects solved both tasks, seven solved the platform task only, three solved the tube task only and five solved neither task.
In fact, Ts1Yah mice performed better in the hidden platform task than their euploid littermates (Pereira et al., 2009; Yu et al., 2010b).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com