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Together with this unique set of proteins in the cascade, Ub chains form the platform for the binding of downstream interacting partners.
The ubiquitination that occurs on K377 of RIP1 (Ea et al., 2006) serves as a platform for the binding of TAK1-binding protein (TAB -TAK1-complex (Kanayama eTAB -TAK1-complexwell as NF-κB essenTAB -TAK1-complexMO (Ea et al., 2006; Wu et al., 2006).
These results suggested that acetylated Lys310 might form a platform for the binding of a bromodomain-containing protein that is required for full transcriptional activity of RelA.
The EJC serves as a platform for the binding of UPF factors, which are considered to be the conserved core of the NMD machinery.
NET components cooperate efficiently to degrade TFPI, and polyanionic nucleosomes, expelled along with NET ejection, serve as the platform for the binding of neutrophil elastase [ 63].
H3K4me3 is a pivotal mark of active chromatin because it acts as a platform for the binding of multiple histone acetyltransferases, histone demethylases and nucleosome-remodeling complexes [ 44, 100].
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Within PREs, Pleiohomeotic (PHO) binding sites and juxtaposed Pc binding elements (PBEs) function as an integrated DNA platform for the synergistic binding of PHO and the multisubunit Polycomb core complex (PCC).
In this platform, the binding of biotin to antibiotin antibody was evaluated.
In parallel with the models for histone acetylation, acetylation of nonhistone proteins may change the activity of these proteins or may serve as a recruitment platform for physical binding of other proteins [reviewed in Sapountzi and Côté (2011)].
CNTs can serve as a platform for concurrent binding of drugs, peptides, high molecular polymers, and other molecules that otherwise cannot be bound to each other.
One widely held model suggests that PRC2 generates H3K27me3 residues that serve as a platform for subsequent binding of PRC1 [ 17].
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