Exact(4)
Questions have been raised about defining the cut off for high platelet reactivity, the optimal time of measuring platelet function on treatment, and whether serial platelet function measurements may be useful [ 39].
Ex vivo platelet function measurements may facilitate risk stratification and personalized antiplatelet therapy.
The antiplatelet effect was sustained over 24 hours for all platelet function measurements.
Recent studies have demonstrated distinct response variability and nonresponsiveness to clopidogrel therapy based on ex vivo platelet function measurements.
Similar(56)
Thus, it may be reasonable to consider both genotyping and platelet function measurement to assess ischemic risk and to guide antiplatelet therapy.
However, there is only evidence from small clinical trials demonstrating the clinical efficacy of changing an antiplatelet regimen based on an ex vivo platelet function measurement.
Personalized antiplatelet treatment with higher clopidogrel doses in selected patients or with newer more potent P2Y(12) receptor blockers based on individual platelet function measurement can overcome some of the limitations of current clopidogrel treatment.
Furthermore, there was no correlation between EA levels and platelet function, as investigated by aggregometric measurements (ASPI-, ADP-, TRAP-test).
Measurements including Platelet Function Analyzer (PFA-100®) closure times, plasma von Willebrand Factor antigen, haemoglobin and platelet levels were made at 32 °C and 37 °C respectively.
By combining both single cell and ensemble measurements of platelet function, this study reveals insight into both the platelet behavior at the cellular level as well as the behavior of platelets in a suspension where they can influence one another.
Methods for the measurement of platelet function.
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