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In arms 2 (AS and oAC simultaneously) and 3 (oAC 1 h after AS), individuals received their first dose of oAC 12 h prior to starting plasma sampling.
Five healthy subjects were recruited by advertising to undergo plasma sampling.
This is of course inherent to any isotopic technique relying upon plasma sampling.
Following the first dose, VGB doses (0.5 g) were repeated at 12 h intervals, with microdialysis monitoring but without further plasma sampling.
In addition, the total DHA concentration was estimated by summation of HPLC-determined DHA and DHA equivalence of the corresponding plasma sampling times of AS for each individual.
Plasma sampling for patients with ALI were performed at baseline, before study drug administration, and on day 3 and 7 as described [ 14].
Subtle differences in experimental design could explain the differences in results such as differences in timing of plasma sampling.
Similar(4)
c Plasma sample.
c Typical mouse plasma sample.
However, this method requires larger plasma sample.
(A) The metabolite-corrected plasma samples.
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