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Plasma samples were obtained over a 14 h interval.

Plasma samples were obtained on admission from SAP patients and at study entry from healthy individuals.

Plasma samples were obtained at the prescribed times and analyzed by liquid chromatography tandem mass spectrometry (LC-MS/MS).

Patient plasma samples were obtained preoperatively, on initiation of cardiopulmonary bypass, after administration of protamine, and 1, 4, 8, and 24 hours postoperatively.There was no early or late mortality in this cohort of patients.

Fasting and postprandial plasma samples were obtained at baseline, three, and six months.

Plasma samples were obtained following the loading and steady-state doses (doses 3-5).

These plasma samples were obtained for another study, using the same setup (data not shown).

Human plasma samples were obtained from eight healthy individuals according to institutional bioethics approval.

Plasma samples were obtained at baseline, 20 min, 50 min, and 120 min for analysis of AC species and amino acids.

Plasma samples were obtained after centrifugation of arterial blood and analyzed using high-performance liquid chromatography for metabolites.

Serum and plasma samples were obtained by centrifuging for 10 min and were stored at −80 °C until analysis.