Differential expression was also found for genes encoding 17beta-hydroxysteroid dehydrogenases (HSD17B2, HSD17B4, HSD17B11 and HSD17B13) and plasma proteins alpha-1-acid glycoprotein (AGP) and orosomucoid (ORM1).
By taking the metastatic-associated gene expression signature generated by Ji et al., in a bioinformatics approach, we discovered a role for miRNA-214 in regulating metastasis of NSCLC and identified four genes (pregnancy-associated plasma protein A, alpha-protein kinase 2, cyclin-dependent kinase 6 and tumor necrosis-factor alpha-induced protein 3) to be involved in this process.
Levels of pregnancy associated plasma protein A (PAPP-A) in the lowest 5% and alpha fetoprotein (AFP) in the highest 5% increase the risk of stillbirth by 50-fold and 2.8-fold respectively [ 4, 5].
To determine if a combination of first and second trimester serum biomarkers (pregnancy-associated plasma protein A (PAPP-A), free βhCG, and maternal serum alpha-fetoprotein (msAFP)) may be utilized to develop a predictive model for adverse pregnancy outcomes.
Myristoylation of G protein alpha subunits is required for localization to the plasma membrane and also facilitating formation of a heterotrimer for G protein signaling.
Alpha-fetoprotein (AFP) is a type of major plasma protein produced in the yolk sac and the liver during fetal development.
Alpha-1-acid glycoprotein (AGP), an extensively glycosylated plasma protein and known binder of drugs (Fournier et al, 2000), changes both quantitatively and qualitatively (in terms of glycosylation) in response to inflammation and disease, such as cancer.
Orosomucoid 1 (ORM1), also named Alpha 1 acid glycoprotein A (AGP-A), is an abundant plasma protein characterized by anti-inflammatory and immune-modulating properties.
Gap junction protein alpha 3, encoded by Gja3, is specifically expressed in the plasma membrane of lens fiber cells to form gap junctions [ 40].
A panel of genes, proteins and metabolites, including PGE2 and TNF-alpha, were identified that describe a diclofenac-response network (68 genes in PBMC, 1 plasma protein and 4 plasma metabolites).
