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Furthermore, a novel component of this hypothesis is that, by removing mediators from the plasma in the setting of systemic inflammation, one can restore the concentration gradient from plasma to infected tissues [ 12].
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Therefore, it seems reasonable to transfuse plasma only in the setting of a severe bleeding with abnormal coagulation tests.
Our results represent the first larger scale study investigating the potential of plasma NGAL in the setting of AHF.
Multiple innate and adaptive factors may thus influence the survival of plasma cells in the setting of chronic inflammation and alter their dependence on BAFF and APRIL [ 35].
First, the levels of miR-124 were not investigated, despite being the most studied plasma miRNA in the setting of cerebral ischemia in animal models [ 17, 18].
These low plasma levels in the setting of a topical approach that bypasses first-pass metabolism in the liver suggest that there should be a reduction in systemic toxicity [ 58, 59, 65, 78, 79].
25 In contrast with earlier studies, more recent studies have failed to demonstrate a significant correlation between erythropoietin production and effective renal plasma flow in the setting of heart failure.
Plasma metanephrine measurements in the setting of clonidine-suppression or glucacon-stimulation were excluded.
Parenteral administration of enfuvirtide in clinical trials has been safe and has resulted in significant decreases in plasma viral load, even in the setting of extensive previous treatment and multi-drug resistance to conventional antiretroviral (ARV) therapy.
Our prior work has demonstrated that hyperresistinemia (plasma resistin >20 ng/ml) in the setting of septic shock and AKI reversibly hinders neutrophil migration in vitro, likely by impairing F-actin formation [10].
In only one patient was renal plasma flow (RPF) determined in the setting of oliguric ARF [ 19].
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