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Among synthetic glucocorticoids, prednisolone has the unique property to bind specifically and with high affinity to plasma corticosteroid binding globulin [ 31].
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Endogenous plasma corticosteroid-binding globulin (CBG) levels were measured at time 0 and 5 h, and hourly from time 0 to 5 h following administration of oral or intravenous hydrocortisone.
For example, plasma corticosteroid-binding globulins (CBG) [ 14, 32- 34], 11β-hydroxisteroid dehydrogenase in saliva and salivary glands [ 35, 36], temperature and pH [ 37] all can affect the disposition of free cortisol.
Both total and free corticosteroid plasma levels were increased after mating in gilts, with significant changes in the maximum corticosteroid binding capacity [ 5].
We have previously described that serum corticosteroid binding globulin (CBG) concentrations are associated with insulin secretion.
Under field and experimental conditions, after an initial large response prolonged stimulation leads to a gradually reducing plasma corticosteroid concentrations.
Fishes display a wide variation in their physiological responses to stress, which is clearly evident in the plasma corticosteroid changes, chiefly cortisol levels in fish.
Corticosteroid binding globulin (CBG) is also found in higher amounts in female than male rats.
These data, therefore, do not support the view that there is an intrinsic corticosteroid unresponsiveness in asthmatic epithelium as a consequence of differential corticosteroid receptor expression, altered ligand affinity, or decreased corticosteroid binding to DNA.
This pattern remained after two weeks in FW, with the exception that plasma corticosteroids returned to pre-acclimation levels.
Therefore we hypothesize that FW acclimation will be accompanied by a decrease in plasma corticosteroids in these animals.
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