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Clearance, or the volume of plasma cleared, is an artificial concept since no portion of the plasma is ever really cleared in this fashion.
Clearance (CL) is the volume of plasma cleared of the drug per unit time (dose/AUC).
Clearance refers to the volume of plasma cleared of drug per unit time via metabolic or excretion processes.
In HD patients, the dialysis dose was calculated as the amount of plasma cleared of urea divided by the urea distribution volume (Kt/V).
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Particularly, plasma triglycerides concentration is reduced after exercise training by increasing lipoprotein lipase activity in plasma clearing triglycerides from circulation and replenishing it to the skeletal muscle stores to the process of excitation-contraction coupling (27).
However, clearance of plasma NT-proBNP occurred across kidney, liver, musculoskeletal, and head and neck tissue [ 26], differ from plasma BNP cleared by NPRs and NEP.
Viremia in plasma was cleared, and the animal showed little evidence of illness by day 14.
K w csf represents the plasma volume cleared in the whole CSF of the animal.
To remove nonspecific background from subsequent screens, either plasma was cleared of IgG prior to fractionation [which did not affect the two-peak SR-A binding pattern] or binding was expressed as the SR-A-specific signal (WT minus SR-A−/−).
Following a single intravenous administration of 4.37 mg/kg suramin, corresponding to one-eleventh the highest human dose allometrically scaled to the monkey (46.5 mg/kg), in male cynomolgus monkeys, suramin was rapidly detected in the plasma and cleared slowly with an average CL of 0.0317 mL/min/kg (Supplementary Figure S3 and Supplementary Table S3).
Fresh plasma was cleared of chylomicrons and precipitates by a 40 min centrifugation at 15000 rpm and 4 °C in a Beckman J2-HS centrifuge with a JA20 rotor, filtered through a 0.22 μm filter (Pall, VWR), and diluted ∼1 1 in running buffer before injection.
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