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The amyloidogenic precursor protein, serum amyloid A (SAA), is synthesized by the liver in response to proinflammatory cytokines and is then transported in the plasma as a component of high-density lipoprotein.
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Furthermore, the UAP1 transcript has also been reported to be detectable in urine and plasma samples as a component of a multi-gene signature [ 28].
By using plasma zinc, a component of the EZP, as an indicator of zinc stores, plasma zinc begins to fall within a week of placing healthy adults on severe zinc depletion; overt clinical symptoms such as skin rash become evident soon after (18).
Plasma is a component of blood, and the process is similar to donating blood.
Best known as a component of blood plasma that is essential for blood clotting, fibrinogen is also found in the extracellular matrix that supports cells, and on the surface of inflamed cells.
Note that we have detected IL-12 subunit p40 in the patients' plasma and that IL-12p40 is known as a component of the bioactive interleukins IL-12 and IL-23 [ 15].
The substrate was presented as PtdIns5 P micelles (6 μM), as a component of artificial plasma membrane liposomes [ 26] or in a hexagonal-phase phosphatidylethanolamine carrier (6 μM PtdIns5 P and 60 μM phosphatidylethanolamine). Recombinant lipid kinase was added to the reaction mixture (200 μl final volume) with 10 μCi of [γ-P]ATP for 10 30 min at 30°C.
The use of convalescent plasma (a component of whole blood) is a second treatment option, but requires much more technical and practical support to ensure safety and good quality management.
These enzymes are produced by: mammals as a component of seminal fluid, plasma and urine [ 1]; bacteria as a virulence factor [ 2, 3]; and venomous animals as a non-toxic component of venoms [ 1].
While MSMB was first identified almost three decades ago as a component of human seminal plasma with FSH-inhibiting activity [ 16], there has been a recent resurgence in interest due to a demonstrated genetic link with prostate cancer susceptibility [ 37- 40].
TF has been shown to circulate in the blood as a component of cell-derived MPs released as fragments of plasma membrane.
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