According to our data calcified plaques show less inflammatory infiltrate, a smaller lipid core, and less neoangiogenesis than other plaques, but with the same incidence of hemorrhage, thrombosis, and surface defects, which define the plaque as histologically complicated [ 10].
Diffusely calcified plaques (13/73) were found predominantly in females (P = 0.017), with a significantly lower incidence of symptoms (TIA/stroke (P = 0.019) than noncalcified plaques but with the same incidence of histological complications (P = 0.156)).
Positive plaques were rescreened with the same serum to obtain the clonality.
Yet, interestingly, in these calcified plaques complications are not correlated with clinical plaque instability (evaluated as symptomatology); indeed, the incidence of TIA/stroke in patients with calcified plaques was sensibly lower than patients with noncalcified plaques, despite the same incidence of intraplaque complications.
Our results suggest that SLE-patients may suffer higher burden of (sub clinical atherosclerotic disease, especially presence of both echolucent and echogenic plaque, than controls with the same bone mineral status.
Thus, it is critical to use neurons not affected by the neurofibrillar and amyloid-β pathology (i.e. neurons whose dendrites are not in contact with amyloid-β plaques) from the same individual when studying how abnormal phosphorylation of tau influences the microanatomy of pyramidal neurons.
Finally, at the far end of the grounds, we reached the memorial -- a line of plaques unveiled in 1967 with the same message in 19 languages.
Positive plaques were re-screened with the same pool of sera to obtain the clonality.
The strong direct correlation of in vivo PiB retention with region-matched quantitative analyses of Aβ plaques in the same subject supports the validity of PiB-PET imaging as a method for in vivo evaluation of Aβ plaque burden.
Plaques were infrequent, small, and structurally simple, having fewer smooth muscle cells and less neo-intimal thickening in comparison with their apoE −/− controls, which displayed large, advanced plaques at the same time point.
