Plaque material was collected from all patients from the common, external, and internal carotid artery.
Pertinent analyses will require fresh human atherosclerotic plaque material characteristics for different disease types.
Research has shown that angiographic techniques can lead to the release of particles, presumably made up of bits of clot and fatty plaque material, into the blood.
Furthermore, inhibition or absence of P2Y12 destabilized the thrombi formed on immobilized collagens or plaque material.
Whereas POAG is characterized by increased juxtacanalicular plaque material and decreased TM cellularity [5], in pseudoexfoliative glaucoma, both plaque material and cellularity are unchanged compared with normal eyes; the characteristic exfoliation material is deposited instead [31].
Blood was perfused over homogenized plaque material, which was isolated from atherosclerotic aortic arches of cholesterol-fed Apoe−/− mice.
In summary, we have shown that ADP, via P2Y12, stabilizes thrombi on ruptured plaques both in vivo and on human plaque material in vitro.
It is possible that the addition of plaque material to the thrombus composition explain the observed differences in T2 values from aspirated material.
Thrombus formation in vitro was assessed in mouse and human blood perfused over collagen or plaque material under variable conditions of shear rate and coagulation.
However, it should be noted that also other thrombogenic components have been identified in plaque material, including tissue factor, oxidized low density lipoproteins and lysophosphatidate [8], [10], [31].
