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In C. elegans, Aβ1 42 forms aggregates similar to amyloid plaques associated with Alzheimer's disease in humans, and leads to age-associated muscle dysfunction and paralysis.
Myoishi, M. et al. Increased endoplasmic reticulum stress in atherosclerotic plaques associated with acute coronary syndrome.
Increased endoplasmic reticulum stress in atherosclerotic plaques associated with acute coronary syndrome: a balancing act between plaque stability and rupture.
Materials: forty-four patients, with 44 plaques associated with various presentations, were studied.
Objective: to identify the echoicity and heterogeneity of carotid plaques associated with ipsilateral symptomatic and asymptomatic neurovascular presentations.
Myoishi M, Hao H, Minamino T, Watanabe K, Nishihira K, Hatakeyama K, et al. Increased endoplasmic reticulum stress in atherosclerotic plaques associated with acute coronary syndrome.
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Plaque associated and neuropil dystrophic neurites and spheroids are prominent features of Alzheimer's disease (Masliah et al., 1993; Terry, 1996; Stokin et al., 2005), and our current data suggests that loss of tau function may lead to neurodegeneration.
So far, clinical studies have focused on the analysis of the characteristics of the atherosclerotic plaque associated with the risk of rupture [13], [14].
These plaques consist of extracellular masses of Aβ filaments and other plaque associated proteins (e.g. apoE, apoJ, inflammatory molecules) which are intimately associated with dystrophic dendrites and axons, activated microglia, and reactive astrocytes [3].
Periodontal disease is a very common chronic inflammatory condition which can be simplistically viewed as a disease caused by the overgrowth of the normal oral bacterial microflora (dental plaque) associated with an exaggerated local host inflammatory response [20].
One of the key differences for bacteria seeking to proliferate in plaque from healthy gingiva compared with the plaque associated with periodontal disease is the availability of various nutrients such as sources of energy and cofactors like heme.
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