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These objects consist of two bracelets, five necklaces and two small plaques as shown in Figure 8.
Results showed numerous rod-like inclusions around amyloid plaques as shown for cofilin in Fig. 5e.
CD163 immunoreactive microglia were closely associated with Aβ plaques, as shown with double staining.
Irregular VIE appearances of the coronary wall were most commonly observed in the mixed type of plaques as shown in the table.
Irregular appearance of the coronary wall is commonly observed in the mixed plaques as shown on VIE since different components are contained within the plaques.
APOE ε4 targeted replacement was also associated with significantly greater co-deposition of apoE in Aβ plaques, as shown by the comparison of apoE-positive plaque load and the level of insoluble apoE between APP/E4 and APP/E2 mice.
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A β immunostaining showed that there is a variety of different types of β-amyloid plaques at early stages, although the majority of plaques were tiny and compact (phase I); and both compact and diffuse plaques were observed at later stages, as shown in the therapeutic protocol (phase II).
Second, compared to non-diabetic individuals, DM patients have a more extensive plaque burden, as shown in several previous studies [ 6, 21] and confirmed by our results, which has a strong influence on MDCT diagnostic accuracy [ 22].
There is increasing evidence that GFAP is not expressed uniformly by all astrocytes [ 50] and that different GFAP isoforms develop in response to plaque-related gliosis, as shown in APP/PS1 and 3xTg AD transgenic mice [ 51].
STX3451 also disrupted adhesion plaques in PNF cells, as shown with phospho-paxillin staining.
Staining with anti-amyloid fibrillar antibodies showed a clear correlation with Aβ and S100A9 depositions within the plaques and blood vessels as shown on the individual and overlapping summary images (Fig. 1e, k and supplemental file 1d, i).
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