In this context, Tian et al. compared morphologic plaque characteristics between culprit and non-culprit lesions and reported that plaque rupture is determined by FCT and a combination of large plaque burden and luminal narrowing is a prerequisite for the development of acute coronary syndromes [ 19].
Thus, we expand the current knowledge by demonstrating that among all morphologic plaque parameters studied by OCT, only minimal FCT, presence of macrophages, mean lipid arc and lipid plaque length are independent predictors of the lesion to be the cause for an ACS in patients with type 2 diabetes.
To investigate the diagnostic value of morphologic plaque features to predict that the lesion is the cause for an ACS, univariable logistic regression analysis was performed.
According to the findings of this OCT-study we conclude that in patients with type 2 diabetes minimal FCT, presence of macrophages, mean lipid arc and lipid plaque length are independent morphologic predictors for acute coronary events.
After the preventive immunization period, activated and/or reactive glia were observed surrounding neuronal plaques (β-amyloid plaques and NFT-like structures), showing a conspicuous morphologic organization in the cortical and hippocampal brain regions of control transgenic mouse brains– 2(i)).
Their results showed that culprit lesions in acute coronary syndrome show specific morphologic characteristics which are characterized by larger plaque volumes, higher remodelling indices, greater proportions of noncalcified material, and presence of spotty calcification.
Early investigations of pathological aging revealed that although senile plaque density was sufficient for AD according to Khachaturian criteria [ 9], morphologic and immunohistochemical differences existed between Aβ deposits in pathological aging and AD.
A recent study demonstrated that a combination of typical LV morphologic change of sCMP and noninvasive demonstration of the absence of significant plaque rupture can be possible alternative diagnostic criteria [ 20].
Additionally, mixed infections may occur where some strains cause plaque formation and others do not, which stresses the importance of the shotgun harvest even when the morphologic features of plaque are present.
In summary, we find that the combination of morphologic and functional information from the MRI with molecular imaging from PET may lead to optimal characterization of the plaque and thus improved individualized counseling and therapy.
