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Hashimoto, T. et al. CLAC: a novel Alzheimer amyloid plaque component derived from a transmembrane precursor, CLAC-P/collagen type XXV.
The ectodomain fragment obtained after cleavage by furin convertase was called CLAC (collagenous Alzheimer amyloid plaque component) and transmembrane collagen XXV as the precursor of CLAC (CLAC-P).
Plaque scores were determined using the plaque component of the Simplified oral debris index (DI-S) by Greene and Vermillion [29].
Plakophilin 1 [174] (PKP1, one of the genes in our panel above) is a desmosomal plaque component [175] that stabilizes desmosomal proteins at the plasma membrane [176], [177] and, with desmoplakin [178], recruits filaments to sites of cell-cell contacts [179].
Serum LDL-C concentration is known to affect the plaque component and volume (27, 28).
Percentages of plaque volume were automatically calculated as each plaque component volume/plaque volume × 100.
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We hypothesize that plaque components are vulnerable to rupture due to plaque progression.
We set out to determine whether high resolution MRI was a valid method of quantifying plaque components in vivo.
To optimize spectral coronary computed tomography angiography (CTA) for quantification of coronary artery plaque components.Fifty-one subjects were prospectively enrolled (88.2% male) (NCT02740699).
A segmentation process is used to generate NURBS-based 3D geometric models of the individual vessel and plaque components at different balloon pressures.
Using 90/Sn150 kVp linear mixed images as a reference, the plaque quantity was similar for 70 keV noise-optimized virtual monoenergetic images whereas low keV images (e.g. 40 keV) yielded significantly higher coronary plaque volumes (all P < 0.001).Spectral coronary CTA with low energy 40-700 keV) post-processing can improve the CNR of coronary plaque components.
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