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Plaque associated and neuropil dystrophic neurites and spheroids are prominent features of Alzheimer's disease (Masliah et al., 1993; Terry, 1996; Stokin et al., 2005), and our current data suggests that loss of tau function may lead to neurodegeneration.
So far, clinical studies have focused on the analysis of the characteristics of the atherosclerotic plaque associated with the risk of rupture [13], [14].
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Plaque-associated microglia in all groups displayed activated morphology (round cell bodies with reduced processes ramification) and some microglia were shown to extend processes into the plaque area (Figures 5g and h).
Plaque-associated Aβ is thought to be highly stable within the brain [17].
Plaque-associated dystrophic neurites were seen in the middle of bundles of extracellular Aβ fibrils.
Plaque-associated astrogliosis was observed in β1- and PBS-treated mice in this age group.
Plaque-associated microglial activation was observed in β1- and PBS-treated mice in this age group (white arrows).
In agreement with the other methods presented here, archaeological dental calculus is estimated to be composed primarily of dental plaque-associated taxa, while dentin is dominated by genera associated with human skin and environmental sources (Supplementary Table S8).
Yin, Z. et al. Immune hyperreactivity of Aβ plaque-associated microglia in Alzheimer's disease.
(i) The number of plaque-associated microglia in the DG was significantly reduced following chronic i.c.v.
(i) A representative confocal image of plaque-associated microglia with double-staining for Iba-1 (green) and MHCII (red).
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