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We find the insights provided can be useful for future model development and planning of experiments.
The planning of experiments was based on Taguchi's L16 orthogonal array.
Issues have been raised regarding the proper planning of experiments and conduct of statistical analyses in these instances.
An important conclusion is that planning of experiments and dose scheduling cannot rely on pilot studies on normal animals alone.
The content of this article will provide useful guidelines for the planning of experiments conducted at the new facility.
In statistical planning of experiments, super-simple designs are the ones providing samples with maximum intersection as small as possible.
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Planning of experiment was based on a Taguchi orthogonal array table.
AF, HB, AN, and TT contributed to the design, planning of experiment, and collected the data.
DS contributed to the design and planning of experiment and behavioural tests, and helped drafting the manuscript.
HK contributed to the design and planning of experiment, and corrected the data and helped draft the manuscript.
KM, KY, and HK contributed to the design, planning of experiment and cognitive tests, and helped performing the data analyses.
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