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We also planned sensitivity analyses to explore the influence of weaning and sedation protocols on these outcomes.
Two additional a priori planned sensitivity analysis were performed.
We also planned sensitivity analyses with inclusion of studies involving GKI regimens or perioperative patients.
To assess the robustness of the results we planned sensitivity analyses that excluded quasi-randomised retention trials.
We also planned sensitivity analysis based on methodological features of the included trials (trials reporting adequate allocation concealment compared with all other trials).
A priori, we planned sensitivity and subgroup analyses to explain the differences among study results and anticipating heterogeneity in pooling across studies for selected outcomes.
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Therefore secondary analyses utilising modelling of the carry-over effect is also planned as sensitivity analyses.
16 We planned a sensitivity analysis to assess for the robustness and consistency of the primary analysis by restricting analysis to trials with a low risk of bias.
Compared with other forecasting techniques (e.g., contingency planning, sensitivity analysis, etc)., SPA shows some advantages in that: it considers combinations of uncertain events, not single uncertainties; it addresses significant interactions among all major variables, not just a few; it is less formalized and more flexible.
Thus in future epidemiological studies of birth outcomes the analytical design will need to consider characteristics of potential spatial and temporal confounders and plan sensitivity analyses accordingly to better interpret results.
If the screening questions outlined above are considered at the stage of writing the statistical analysis plan, sensitivity analyses will be relevant to the clinical question, and the number to perform and report will be reduced.
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