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Furthermore, by explicitly including the impact of tumor motion on radiobiological models of cell survival, planned radiation dose could be optimized to improve radiobiological metrics of treatment plan quality, which include tumor control probability, normal tissue complication probability, and generalized equivalent uniform dose[88].
Prior or planned radiation therapy to a single site of evaluable disease in the event that the lesion was the only site of evaluable disease was also an exclusion criterion.
In this study, we illustrate that the accumulated and planned radiation doses may not always be in agreement for MLC treatment fields at an SAD unless the offset is carefully adjusted.
Two patients in the BS group had not completed planned radiation therapy because they developed severe myelosuppression (leukopenia and thrombocytopenia), and were excluded from the evaluation of clinical response (Table 1).
Ten patients (67 %) had an Eastern Cooperative Oncology Group performance status of 3 and 14 patients (93 %) were in palliative prognostic index group B or C. The median total planned radiation dose was 30 Gy in 10 fractions.
Planned radiation therapy was completely delivered in 15 of 17 patients (88percentt) of the older age group and in 106 of 115 (92 percent) of the younger age group (p > 0.05).
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Baseline interviews were conducted on the day the patient had an appointment at the simulator to plan radiation treatment or received their first radiation treatment.
The role of CT in staging PCa is reserved for the search for lymph node metastasis, evaluation of advanced disease, and planning radiation therapy.
Demonstration of disease in normal sized lymph nodes could be of particular importance for planning radiation therapy given that the quality of radiation therapy delivery has a major impact on overall survival [ 12].
Likewise, there has been no published data yet on the role of PET/CT in planning radiation treatment although this is likely to show similar advantages as in other tumours[ 20 ].
Another study, which included 18 patients with advanced squamous cell head and neck cancer, evaluated the role of [F]FAZA PET imaging to identify hypoxia in order to plan radiation treatment.
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