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The publisher is expecting a major best seller, with a planned print run of 300,000 copies in hardcover.
The enormous early interest in the book prompted Dutton to increase the planned print run to 400,000 from the original 300,000.
The New England Journal of Medicine posted the paper on its Web site, ahead of its planned print publication on June 14.
Christine Ball, a spokeswoman for Dutton, also said on Tuesday that the publisher had increased the planned print run to 575,000 hardcover copies from the original total, 300,000.
When editors at the University of California Press pondered the possible demand for "Autobiography of Mark Twain," a $35, four-pound, 500,000-word doorstopper of a memoir, they kept their expectations modest with a planned print run of 7,500 copies.
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The guild plans print ads and more videos over the next two weeks.
In looking at the product plans printed in trade publication Automotive News, it seems as if they plan to kill off Mercury.
Houghton Mifflin originally planned to print 25,000 copies, but is now expected to print far more.
Brian Ulicky, a spokesman for Simon & Schuster, said the publisher planned to print 60,000 copies.
Though Hasbro had not planned any print ads this year, it agreed.
James Kelly, editor in chief of Time, said the magazine planned to print eight million copies.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com