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In this study we address the stimulus-polarity problem posed by the dual planar polarization of hair cells in the lateral-line system of the zebrafish.
The planar polarization of developing tissues is controlled by a conserved set of core planar polarity proteins.
Asymmetric distribution of Fz and Vang further underlies the local coordination of planar polarization by contributing to the cell-cell propagation of polarity (reviewed in [9], [10]).
In both cases, this requires planar polarization of the epithelium, suggesting that the planar cell polarity pathway [60], [61] may be involved.
As one efferent neuron can contact all hair cells in a neuromast, not discriminating polarities, a role by the efferent system in the planar polarization of hair cells is unlikely.
The cells, therefore, display a morphological planar polarization.
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The Wnt/PCP pathway is responsible for asymmetric distribution of cytoskeleton and cell polarization via cell planar polarity and cytoskeletal reorganization, respectively [ 39].
More recently, in the zebrafish, transgenic GFP-labeled cilia have revealed requirements for planar polarity proteins in ciliary polarization [ 10] and permitted precise measurements of in vivo ciliary motility [ 11].
Planar polarity proteins are acquired at embryonic day 11.5 synchronously to apicobasal polarization of pancreas progenitors.
This represents an alternative to the previously described models of planar polarity in which the core PCP components are thought to drive the polarization of the actomyosin network.
The a-p orientation of the SOP division relies on the planar cell polarization of the single-layered notum epithelium [4], [6], [7], [8].
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