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In 1966, academics and a lawyer sat down in a Long Island living room with a high school teacher, students and housewives to plan the trial that would give birth to the Environmental Defense Fund.
At the current sample size, as detailed in the Analysis plan, the trial will allow for estimates of the proportion of subjects who experience an adverse event in the MSC and placebo-treated arms as well as the standard effect size of MSCs for clinical outcomes.
Early PPI "You've got to plan ahead" Begin planning PPI and consulting with contributors when starting to plan the trial.
Box 1 Tips for planning and implementing patient and public involvement (PPI) in clinical trials Early PPI "You've got to plan ahead" Begin planning PPI and consulting with contributors when starting to plan the trial.
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To explore characteristics of clinical trials that influence the choice of the noninferiority margin (NIM) when planning the trial.
LE planned the trial statistics.
ADJ, MWM, AH, and JD developed the study protocol and planned the trial.
HR and JD developed the study protocol and planned the trial.
LJK made substantial contribution in planning the trial, drafting the manuscript and analysing data.
MWM, CWK, and JD developed the study protocol and planned the trial.
MWM, JK, ADJ, and JD developed the study protocol and planned the trial.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com