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Several characteristics of the index drug prescription claim were also captured: the days' supply, mail-order status, fixed-dose combination with metformin, cost-sharing index, which was the average patient out-of-pocket cost for a 30-day supply, calculated annually for each study drug for each insurance plan in the database, and index regimen [ 24].
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Program in the database info.
In other words, our method depends on the quality of treatment plans in the RTP database.
All analyses were predefined in the statistical analysis plan before the database lock in September 2014, and were conducted using SAS version 9.3 (Cary, NC, USA).
Furthermore, we are planning to incorporate in the database high-precision data by mining and extract information from the literature in an automated way.
Only health-care plans that submit data for all plan members are included in the database, ensuring complete data capture and representative samples.
Furthermore, only health-care plans that submitted data for all plan members are included in the database, ensuring complete data capture and representative samples.
In addition, we plan to update the database in a next iteration to include the latest genome build (HG19) and the newest available SNP mapping (dbSNP 132).
Also, our analysis is based on actual costs paid by health-care plan providers in the PharMetrics database, as opposed to applying standard unit costs to resource-use profiles in a not-for-profit health maintenance organization, which may have the effect of underestimating the cost of care of these patients relative to our setting.
However, the optimal plan executed by the database engine in a distributed hybrid deployment can be different from the one observed during profiling.
We plan to update the database presented in this paper every year.
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