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Serum 25-hydroxy vitamin D levels are useful to determine reserves of vitamin D and to plan doses for supplementation.
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Previous experience with a similar vaccine (JEV-PIV) helped to plan dosing and schedule.
In the SIB HDR brachytherapy plan dose levels were optimized to match the TCP of the 10Gy HDR brachytherapy plan for the PTVDIL and remaining PTVHDR.
While processing the 4-F IMRT plan optimization the cTF plan dose distribution was hybrid into the procedure with the optimization type setting as "None".
Thirty-one (76%) patients and 36 (88%) patients received all nine planned doses of cetuximab and full three doses of planned chemotherapy, respectively.
Planned doses for various field sizes and wedge angles were measured for verification and the differences were found to be less than 1.8%.
Planned doses of chemotherapy were well respected (Table 2).
All 5 planned doses of daclizumab were given to 53% of patients (median 5 doses, range 2 5) and all 4 planned doses of infliximab were given to 53% of patients (median 4, range 1 4).
The good tolerability of this regimen was also reflected by the high median percentage of the planned doses delivered (93%).
The ability to deliver the planned doses of irinotecan should lead to improvement of the efficacy of this combination regimen.
We set no study target and a patient who completed the accelerated regimen within the planned time and received all planned doses had a dose-density of 1.5.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com