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With respect to this eventuality, field observations measuring plague incidence and severity would be warranted to assess the potential of lovastatin for lowering plague incidence and severity in individuals receiving lovastatin as part of anticholesterol treatment, and exposed to plague endemic countries.
The complex dynamics governing high plague incidence in this region are not fully understood despite extensive research but most likely involve climate, mammalian reservoirs, vector species, and habitat ecotypes (4, 7, 14 ).
A global trend of decreasing plague incidence from 1950 to 1980 was followed by decreased financial support for appropriate diagnostic facilities, lowered interest of the health care authorities and ultimately the deterioration of surveillance systems for the disease.
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Here, using a flea-to-mouse transmission model, we show that a Y. pestis strain lacking the Ybt system causes fatal plague at low incidence when transmitted by fleas.
Both mutants are avirulent by the ID route and fully virulent by the IV route, but cause plague at low incidence following fleabite, despite the fact that their LD50 by the ID route (>105 CFU) is several orders of magnitude higher than the number of CFU transmitted by blocked fleas (median <100 CFU) [2], [17], [18].
From 1949 to 1995, zoologists at the Kazakh Scientific Center for Quarantine and Zoonotic Diseases carefully recorded the incidence of plague among the region's great gerbils and fleas (Science, 30 April 2004, p. 673: http://www.sciencemag.org/cgi/content/full/304/5671/673).sciencemag.org/cgi/content/full/304/5671/673
When Stenseth's team correlated those statistics with climate data, they found that spring warmth and summer rains, which led to more abundant rodent and flea populations, were the most important factors leading to an increase in the incidence of plague.
The incidence of plague differed sharply according to districts: most patients (82.9%) lived in Area 1, which pools the most unhealthy and densely populated districts of the town.
In addition, few data are available for the Chinese who are plagued by an increasing incidence of diabetes (9).
The city of Chicago has been plagued by horrific incidences of gun violence, as more and more lives have been claimed, particularly in the city's south and west sides.
Most of these cases are the bubonic form of the disease, usually a consequence of the transmission of bacteria to humans via bites from fleas that have previously fed on infected rodents although contact with domestic cats that have been exposed to Y. pestis is another important transmission mode because of the higher than average incidence of pneumonic plague that occurs in these cases [1].
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com