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In addition, the specificity of our findings for the pregnancy period places important limitations on possible residual confounding.
The iSPOT-D trial is a naturalistic study, and as such, lacks a placebo arm, this places important limitations on how we can use this data to understand the brain circuits that govern remission — the most critical of these being differentiating the specific effects of ADM therapy from spontaneous remission.
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Feasibility and ethical considerations placed important limitations on the research design; the study lacks a control group unexposed to services, and families were not randomly assigned to a program model.
The paucity of such data placed two important limitations on our review.
Despite its significant findings, the present investigation should be placed in the context of several important limitations.
There are, however, important limitations on what conduct remedies can accomplish.
We recognize several important limitations.
The study has important limitations.
Our study has important limitations.
There are a few important limitations to the study.
However, they have important limitations.
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