Adding side chain atoms not built in the original structure or flagged as 'not there' by setting the occupancy to zero (common practice of many crystallographers to denote disorder), or changing their placement, changes the calculated electrostatic potential of a protein and can affect drug docking studies and simulations.
Many of the arrangements used are problematic: either they produce results that are very sensitive to electrode placement, change the potential distribution, do not provide a uniform current density and overpotential at the electrode or require delicate patterns liable to fail.
Specifically, a + 1 mm horizontal change from the center placement changes the major axis angle to −51.4 degrees compared to the previous value of −35.2 degrees.
BUDZ, which doesn't yet file with the SEC but is in the process of doing so after having filed a Form S-1 to register 8.98 million shares held by investors in prior private placements, changed its name to its current one in early 2015.
There is ongoing debate regarding the impact of youth behavior problems on placement change in child welfare compared to the impact of placement change on behavior problems.
The Project Regions reported considerably lower placement changes (M = .33) than the Comparison Region (M = .98).98
Because the intervention program has components specifically designed to prepare foster children for placement changes and to maintain consistent parenting techniques despite them, a prevention effect on HPA axis dysregulation during placement changes was hypothesized.
These efforts have been driven by evidence of negative outcomes for foster children who experience frequent placement changes.
Specifically, as worker contact increased, the likelihood of placement change decreased [B = − .28, W (5.35, p = .02)].
