The nonlinear forest transition curve can provide both a theory of change (similarity of processes) and a theory of place (configuration of state variables).
Optimised hardware is generated automatically from such descriptions in the form of fully placed configurations in EDIF format, or VHDL.
These data support a pivotal role for mGluR5 in both hippocampal LTD and the acquisition of object-place configurations.
Our data support that mGluR5 is critically required for both electrically induced and learning-facilitated LTD, as well as the learning of object-place configurations.
However a recent report suggests that hippocampal place cell activity does not drive the re-exploration of novel object-place configurations during an object-in-place task, but rather represents a general novelty signal [96].
We reported previously that induction of LTD is facilitated by exploration of novel object-place configurations during application of a subthreshold LFS (Manahan-Vaughan and Braunewell 1999; Kemp and Manahan-Vaughan 2004).
In this paper, we present a case study in which we constructed a user interface for "pick-and-place configuration" of the Flexible Assembly Unit FAU.
In the third exposure, control animals explored the now familiar objects but in a rearranged object-place configuration.
Animals responded upon reexposure to the same object-place configuration as if they had never seen this configuration before, and under these circumstances, LTD was facilitated.
Here, a similar effect was seen, but in MPEP-treated animals, no habituation was evident when animals explored the object-place configuration for a second time (Fig. 10).
The responses of the control animals replicated the effects seen in the previous experiments: first exposure facilitated LTD, and reexposure to the same object-place configuration did not.
