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Out of 90 randomized subjects, 86 had data for safety analysis; and 84 had data for PK analysis.
We combined these data with previously collected adolescent PK data and performed a population PK analysis.
We analyzed the data using a population PK analysis approach and included samples from two additional pediatric trials.
First, saturation of clearance (from PK analysis) signifies the saturation of the targets when the target is readily accessible.
Blood for PK analysis was collected in microtainer plasma separator tubes containing lithium heparin via retro-orbital bleeds.
For study I, 282 signals and for study II 302 signals were used for pk analysis.
Importantly pharmacokinetic (PK) analysis of rapamycin in dogs has not been reported.
BJA performed the population PK analysis.
Samples from 28 patients were available for PK analysis.
PK analysis was performed by using a noncompartmental approach.
PK analysis revealed that exposure to pateclizumabwas approximately dose-proportional.
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