Simultaneously, these findings provide an enormous challenge to medicinal chemists and (chemical) biologists alike to devise novel strategies to inhibit the inhibition of pivotal nuclear factors, such as PRC2, by pathological histone mutants.
Therefore it remains pivotal to define measures of protein similarity that are highly functionally relevant, and then to devise analysis techniques that draw correct functional inferences from them.
The perivascular cell in endometrium is pivotal in both menstruation and early pregnancy and we need to understand this cell better to devise more effective medical treatment for menstrual dysfunction.
The advances in understanding the complex and interactive nature of MECP2 and its regulatory elements are pivotal to unraveling the mechanisms underpinning the development and progression of complex and poorly understood neurodevelopmental disorders and to devise novel therapeutic approaches.
"We deferred to them to devise a plan".
If only it were easy to devise one.
To devise an effective postoperative analgesic protocol.
Hearing about IdeaSpace inspired him to try to devise one.
This jealousy led him to devise a "human camera".
What corporate reformers manage to devise continues to amaze me.
