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Through the use of a common pivotal structure, a new C-galactoside ester analogue (23) was synthesized which showed an encouraging TH2 biased response during preliminary biological tests.
It was suggested that the terminal loop is a pivotal structure where miRNA processing 'activators' (for example, KSRP) function in a coordinated way to convey proliferating, apoptotic or differentiating cues into changes of miRNA expression.
In addition, the insular cortex is a pivotal structure in the greater limbic lobe and plays a role in diverse functions linked to emotion and memory [ 14].
Once activated, NLRP3 proteins associate with other cytosolic proteins to form an inflammasome presently known as a pivotal structure in the inflammatory process and in diseases in which IL-1β is greatly involved.
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The robust, evidence-based good practice guidelines created will be pivotal to structuring and informing existing and future S&T networks, as well as to establish the UNISDR Science and Technology Roadmap and, ultimately, contribute to meeting the targets of the Sendai Framework.
Detection, comparison and analyses of binding pockets are pivotal to structure-based drug design endeavors, from hit identification, screening of exosites and de-orphanization of protein functions to the anticipation of specific and non-specific binding to off- and anti-targets.
"Bivalent domains" are pivotal chromatin structures composed of both repressive (H3K27 methylation) and activating (H3K4 methylation) marks that silence developmental genes while preserving stem cells' ability to be activated in response to appropriate developmental cues.
One respondent said, 'We would stress the importance of the need to involve emotional aspects simply because to exclude them would ignore the 'heart' which has been pivotal to the structure of [these] rural areas for centuries.'' (p.29).
Herein, various pivotal parameters affecting structures and properties of the nanocomposites including various types of modification as well as a vast range of available dispersion techniques were discussed.
Since the founding of the People's Repbulic of China, the state has played a pivotal role in structuring inequality (Bian 1994).
Parasites play pivotal roles in structuring communities, often via indirect interactions with non-host species.
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