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Iron is a pivotal nutrient for cell growth and cell cycle regulation, so iron chelators may be useful for the treatment of cancer [ 7].
Iron is required as a cofactor for the catalytic activity of HPHs [ 6], and is also a pivotal nutrient for cell growth and cell cycle regulation [ 7].
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The placenta plays a pivotal role in nutrient transfer, growth, and organ development and these processes are regulated by mitochondria.
The tegument plays a pivotal role in nutrient uptake [ 43- 45] and locates at the interface of the parasite and its host.
Progress in this field has led to the cloning of regulatory genes that play pivotal roles in nutrient-induced changes to root development.
Intestinal microbiota may play a pivotal role in converting nutrients into energy.
The soil ecosystem provides a habitat for numerous and diverse fauna which hold a pivotal role driving decomposition and nutrient cycling.
Deregulated nutrient signaling plays pivotal roles in body ageing and in diabetic complications; biochemical cascades linking energy dysmetabolism to cell damage and loss are still incompletely clarified, and novel molecular paradigms and pharmacological targets critically needed.
In the next sections, we review pivotal roles of these three nutrients in modulating immune responses.
Both the proteasomal and autophagocytic pathways play pivotal roles in this, releasing nutrients for re-cycling during periods of fasting and removing damaged or unnecessary organelles.
Autophagy plays pivotal roles in the stress response, nutrient deprivation, damaged organelles, unfolded protein aggregation, intracellular quality control and cell death.
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