Furthermore, we discovered the Rho-GTPase homolog SmRho1 of S. mansoni as a first pivotal interaction partner of SmDia.
The local immune response to bacteria, including live BCG, is complex, but the presentation of bacterial antigens by APC to T-helper cells is the pivotal interaction (Alexandroff et al, 1999).
For PPIs that are mediated by the formation of an intermolecular β-strand, the situation is different, with most pivotal interactions being specific hydrogen bonds between the proteins augmented by some side chain interactions that are located in usually shallower subpockets.
However, this activity is not conserved in yeast cells and the hClp1 ATP-binding homologous domain is pivotal for interaction with Pcf11 [74].
In this scenario, molecular structures of HS, for example, sulfation pattern and chain length, are pivotal in interaction between endothelial cells and leukocytes as well as with the soluble inflammatory cytokines.
In the BRCT domains of all three polymerases, α-helix 1 is pivotal to interactions with the end-joining factors, with structural variations in the interaction surface observed among the three.
The aim of this study was to define the pivotal molecular interactions involved in recognition and lysis of RMS cells by resting and activated NK cells.
It could be shown that for Pc several charges are pivotal for the interaction.
The Cys residue, which is pivotal in the interaction of Trx-dependent GPx with Trx, could not be defined in the platyhelminth proteins, as well as in the nematode and mammalian PHGPxs [ 5, 18].
Thrombosis on top of an atheromatus unstable plaque is now accepted as the most common mechanism underlying acute ischemic syndromes (ACS), and in that process platelet dysfunction plays a central pivotal role through interaction with the vessel wall.
In agreement with this hypothesis, the different action of ceramide on SGK-1 and AKT-1 may be, at least in part, dependent on the absence of pleckstrin homology (PH) domains in SGK-1, which is pivotal for the interaction of PDK-1 and AKT-1 with plasma membrane phosphoinositides, modulating its activation.
