With respect to RCTs, data from initial pivotal trials were discussed.
4 Several proteins of the ECM contain this tripeptidic motif, vitronectin (Vn) being one of the most prominent ones.[ 2a, 5 The integrin subtype αvβ3, which primarily binds to Vn, plays a pivotal role for initial cell adhesion.
The relatively short durations of the initial pivotal randomized placebo-controlled trials involving atomoxetine HCl for the treatment of attention-deficit/hyperactivity disorder (ADHD) provided limited insight into the time courses of ADHD core symptom responses to this nonstimulant, selective norepinephrine reuptake inhibitor.
While one of the researchers (SS) is integral to the development of the supervisory model, any bias that may have resulted was mitigated through researcher one (MC) and researcher two (RR), taking a pivotal role within initial data collection and analysis.
After the initial pivotal randomised phase II BOND study which demonstrated the ability of cetuximab to circumvent chemotherapy resistance (Cunningham et al, 2004), a series of randomised phase II III trials for EGFR-targeted monoclonal antibodies (mAbs) have been reported.
Owing to registration and commercial obligations, the initial pivotal studies with bevacizumab, sorafenib, sunitinib and pazopanib were carried out using either placebo or IFN as a comparative reference arm (Motzer et al, 2007; Escudier et al, 2007b; Sternberg et al, 2010).
Alveolar macrophages play a pivotal role at the initial innate immune response against infection of tubercle bacilli via the respiratory tract [1].
Epithelial mesenchymal transition is regarded as a pivotal event in the initial step of a metastatic cascade.
Therefore, our analysis combining expression and TF regulatory data suggests that FOXA1 could be the potential negative regulator of EMT and could play pivotal roles in the initial steps of lung cancer metastasis.
Adhesion of bacteria to the epithelial cells is believed to be an initial and pivotal event in the pathogenesis of most bacterial enteric infections and is necessary for allowing bacteria to survive and persist in a continuously moving environment and to defeat host defense mechanisms [ 6].
