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Prostaglandins are lipid mediators produced by cyclooxygenases from arachidonic acid, which serve pivotal functions in inflammation and pain.
The Environment-related parameters, including pH, oxygen level and viscosity play pivotal functions in controlling the physical, chemical and biological performance of local molecules.
Operating on the inductive and effective phases of an anti-tumor immune response and uncovering pivotal functions that may reduce cancer cell growth, interleukin-18 (IL-18) appears to be an attractive candidate for the sustained local adjuvant immunotherapeutic treatment of brain gliomas.
This prompted us to investigate whether SSTRs affect pivotal functions of keratinocytes i.e. proliferation and migration and whether we can find receptor subtype specific differences.
Taken together, these observations show that Activin, BMP and FGF signalling play pivotal functions in cell fate specification of pluripotent stem cells.
This notion is supported by a previous study showing a higher concentration of FGF2 in follicular fluid compared to serum [29] and suggests that FGF2 production from the ovary has pivotal functions during follicle development and oocyte maturation.
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Even the stories that lack a pivotal function in the plot, like the reverential one about Paul Robeson, contribute to the broader message: that some neighborhoods can always find hope in a dream.
Both gene products are known to have a pivotal function in pain mechanisms, thus making these associations particularly stimulating.
Our current understanding of the role of the FA proteins reflects their pivotal function in the surveillance and maintenance of genomic integrity.
In this context, sialidases, the glycohydrolases that remove the terminal sialic acid at the non-reducing end of various glycoconjugates, perform an equally pivotal function.
Both abnormalities in the distribution of B cells subsets and clinical benefit response to B cell depletion in autoimmune diseases, highlight their pivotal function.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com