Sentence examples for pivotal function of from inspiring English sources
Here, we review recent progress on subtype-specific subcellular localization, participation in signaling cascades, and the pivotal function of α1-ARs, as delineated through studies on genetically engineered animals.
All of these results illustrate the pivotal function of CCL19 in clinical settings.
The second pivotal function of storing genetic information as a DNA protein complex is the additional layer of regulation that this feature provides.
An in vitro study has highlighted the pivotal function of normal Htt in the differentiation of embryonic stem into hematopoietic cells.
Here, we used conditional Glis3-deficient mouse models to demonstrate the pivotal function of Glis3 in controlling insulin gene expression in the adult pancreas in vivo.
Given pivotal function of p53 in tumour suppression, it is no surprise that the p53 gene is the most frequent target for genetic alterations in human cancers (Hollstein et al, 1996).
This prompted us to investigate whether SSTRs affect pivotal functions of keratinocytes i.e. proliferation and migration and whether we can find receptor subtype specific differences.
Particularly, GABA-T was found to play a pivotal function and impairment of this step was responsible for a decrease in salt tolerance indicating that GABA catabolism was a determinant of Arabidopsis salt tolerance.
These results are in line with previous findings regarding the crucial role of p55 TNFR in the control of adhesion molecules expression by endothelial cells at inflammatory sites [11], [18], [19], and extend this pivotal function also to sites of developing atherosclerotic lesions in a physiological hyperlipidemia induced model of the disease.
The evolutionary origin of its pivotal function has remained enigmatic and the discovery of two p53 siblings in vertebrates p63 and p73 further added complexity to this question because of their high functional diversity.
Our current understanding of the role of the FA proteins reflects their pivotal function in the surveillance and maintenance of genomic integrity.
