As dynamic structural changes are pivotal for the functions of some classes of RNA molecule, it is important to develop methods to monitor structural changes in RNA in a time-dependent manner without chemical modification.
This complex auto-regulatory loop, composed of miR168-guided AGO1-catalyzed cleavage of AGO1 mRNA and AGO1-mediated stabilization of miR168, was shown to ensure the maintenance of AGO1 homeostasis that is pivotal for the correct functioning of the miRNA pathway.
The integrity of the endoplasmic reticulum (ER) and the juxtaposed mitochondria is pivotal for the proper function of the cardiomyocyte.
In eukaryotes, the 26S proteasome handles the majority of regulated proteolysis and is pivotal for the proper function of the cell [ 1, 2].
In addition the maintenance of the integrity of the ABB is pivotal for the physiological function of the lungs and limits the passage of inhaled material to the blood circulation.
The VFT2 domain is totally conserved within each of the two major BvgS types, indicating its pivotal role for the function of the protein.
Synchronization of neurons may be pivotal for optimal brain functioning [8], but it can also reflect abnormal dynamics related to epilepsy.
By the pull-down assay, the CTFβ of APP interacts with the N-terminal half (amino acid residues 2 132; NTF) of AQP1 spanning the transmembrane helices H1, H2, and H3, which contains one of two NPA motifs pivotal for water transport function [ 2, 32].
Furthermore, other processes such as cellular localization of proteins and cellular morphology processes are mediated by protein binding events and are pivotal for cells and the functioning of the body.
