Sentence examples for pivotal factor of from inspiring English sources

Posttranslational modification of PFK1 enzyme might be the pivotal factor of deregulated glycolytic flux in tumors that in combination with altered signaling mechanisms essentially supports fast proliferation of cancer cells.

Indeed, recent reviews have considered the imbalance between anabolism and catabolism as a pivotal factor of the IVD degeneration process.

SMAD4 is the pivotal factor of canonical SMAD signaling and its inactivation or deletion prevents SMAD signaling.

Smads are the key intracellular mediators of transcriptional responses to TGF-β signaling, and among these Smad4 is the pivotal factor of the TGF-β pathway as it functions as a key tumor suppressor [ 24- 26, 29- 31].

The theory of reasoned action (TRA) and the theory of planned behavior (TPB) may assert that this attitude is a pivotal factor of the subsequent behavioral support and, accordingly, assist in tackling the low support problem with pragmatic solutions [ 42, 43].

The predominant downregulation of miR-126 in progressive RCC suggest miR-126 to act as a tumour suppressor, which is supported by the recent description of miR-126 regulating VEGF-A in RCC [ 16], one of the pivotal factors of angiogenesis and tumour progression.

A research by Fairchild and Mackinnon [6] revealed that organizational learning capability (OLC) is pivotal factor for adoption of system and technological solutions.

The authors also proposed that glomerular PECs could function as a progenitor cell niche for podocytes and under proper settings could proliferate and transdifferentiate into podocytes, which may be a pivotal factor for the regression of DN [ 31].

P. gingivalis FimA is a pivotal factor for mediating the adherence of bacteria to host cell [6].

The findings verified that miR-34a is a pivotal factor for the anti-proliferative activity of ART and AS [83].

Interestingly, a recent study from Japan demonstrated lower efficacy of 5-FU-based chemotherapy in HIF-1α-expressing human gastric adenocarcinomas, strengthening the perception of HIF-1 as a pivotal factor in the determination of gastric cancer chemoresistance [31].