Sentence examples for pivotal control from inspiring English sources

The strength of mTORC1 activation appears to be a pivotal control switch that determines effector versus memory CD8 T-cell differentiation 9, 27.

The choroid plexuses develop early during embryogenesis and provide pivotal control of the internal environment throughout development when the brain is especially vulnerable to toxic insults.

It was also reported that PRLHR, as well as involvement in the physiological responses to central dministration of PrRP, may play roles in other processes, such as feeding behavior, pathogenesis of uterine fibroids, energy expenditure, obesity and the pivotal control of blood pressure [ 8, 23, 24].

The pivotal Diabetes Control and Complications Trial (DCCT) and Epidemiology of Diabetes Interventions and Complications (EDIC) study demonstrate that poor glycemic control is associated with an increased risk of developing complications in type 1 diabetes (1).

To make sure that remains FA has no detrimental on human health, it is pivotal to control the FA level via early detection.

This in turn led to three pivotal randomised control trials that investigated the role of CRT.

As in the management strategies for RA, early diagnosis and introduction of effective treatment is pivotal to control inflammation, and prevent damage and disability.

In the pivotal Diabetes Control and Complications Trial (DCCT), investigators compared the use of intensive therapy with conventional treatment among 1,441 patients with type 1 diabetes.

Despite incremental improvement over the past 90 years clinical outcomes remain suboptimal with fewer than 5% of patients in the intensively treated group of the pivotal Diabetes Control and Complications Trial achieving glycaemic targets.

DOI: http://dx.doi.org/10.7554/eLife.04871.002 Reversible phosphorylation of the alpha subunit of translation initiation factor 2 (eis2a) is pivotal to control of global rates of protein synthesis and to modulating mRNA-specific translation in eukaryotes (Sonenberg and Hinnebusch, 2009).

Regulatory T cells (Tregs) are thought to be pivotal in controlling both autoimmune and allogeneic undesired immune responses.