Sentence examples for pivotal cellular functions from inspiring English sources

For genes playing pivotal cellular functions, such as p16 and other tumor suppressors and senescence-associated proteins, such multi-leveled, complex regulatory networks are expected.

Direct cell-to-cell communication is a pivotal cellular function of multicellular organisms.

Because autophagy has a pivotal role in cellular functions, considerable attention has been focused on the relationship between autophagy and cancer.

Dynamical properties are considered to be pivotal in determining cellular functions such as apoptosis, cell division, proliferation, etc. [ 34], and it follows that differential dynamical properties can serve as important indicators for discovering the role of specific biological processes in causing the malfunction of cells.

Activation of this pathway plays a pivotal role in essential cellular functions such as survival, proliferation, migration and differentiation that underlie the biology of human cancer.

Therefore, the RhoA/ROCK signaling pathway is proposed to play a pivotal role in diverse cellular functions, including expression and activity of endothelial nitric oxide synthase, vascular smooth muscle contraction, actin cytoskeleton organization, cell adhesion and motility, proliferation, and hypertrophy in smooth muscle cells (Noma et al. 2006 Somlyo and Somlyo 2003 Gerthoffer 2003 Gerthoffer

This subtype is associated with abnormalities in the AKT/PI3K signaling pathway which plays a pivotal role in modulating cellular functions such as proliferation, growth, survival, and metabolism in response to extracellular cues mediated by cell surface receptors and G-proteins.

Therefore, we investigated the key signalling pathways, PI3K/Akt and MAPK/ERK, which are involved in AP-1 activation [30], [31] and play a pivotal role in basic cellular functions such as cell growth, survival, migration, angiogenesis and tumorigenesis [28], [29], [42].

The ERK/MAPK cascade plays a pivotal role in several cellular functions.

PI3K/AKT and MEK/ERK pathways have pivotal role in fundamental cellular functions such as cell proliferation, cell growth, and survival by phosphorylating a variety of substrates.

MiRNAs play a pivotal role in many cellular functions by regulating normal developmental and physiological processes [ 5- 7], and are involved in disease development [ 8, 9].