Exact(14)
The pivotal cell involved in fibrosis and leading to cirrhosis is the hepatic stellate cell.
Insulin-like growth factor-I (IGF-I) provides pivotal cell survival and differentiation signals during inner ear development throughout evolution.
P53 is a pivotal cell fate determinant due to its role in regulating cell-cycle progression and apoptosis in response to cellular stress and constitutes the most commonly mutated gene in human cancers [33].
For example, miR-222 targets p27 and p57, which are both pivotal cell cycle inhibitors [ 79].
Trifunctional probes were used to identify several protein targets involved in some pivotal cell processes.
RGCs are a pivotal cell type in the developing CNS of all vertebrates and are a specific group of neural stem cells.
Similar(46)
Second, our target tissue was circulating leukocytes, the pivotal cells that mediate host immune response to critical illness.
These pivotal cells arise early during embryonic development and provide both developmental support and immune protection to the brain.
Stimulation of OBA9 cells with purified Omp29 increased the phosphorylation of focal adhesion kinase (FAK), a pivotal cell-signaling molecule that can up-regulate actin rearrangement.
The identification of new protein factors, which mediate cell growth in RMS, such as TBX2, may connect the deregulation of the PI3K pathway with histone deacetylation of the genes encoding pivotal cell-cycle regulators such as p21.
The observations suggest that fibroblasts are the pivotal cells in the renal interstitium.
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